Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth
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منابع مشابه
Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via E2F2. This stress consequentially inhibited ce...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.16432